Mounjaro®

About Mounjaro® (Tirzepatide)

What is Mounjaro®?
Mounjaro® KwikPen (tirzepatide) is a new injectable weight loss drug. It’s like your body’s natural GLP-1 and GIP hormones found in your intestines. It helps you manage your appetite and feel fuller for longer periods. It works with a reduced-calorie diet and increased physical activity to help you lose weight in a healthy way.

Although women may search for a weight loss pill Mounjaro, the treatment is actually administered as a once-weekly injection rather than a tablet, helping to regulate appetite and support weight loss alongside a healthy diet and exercise.

Who can take Mounjaro?
Mounjaro is only available on prescription. It can be used for people who meet the weight-loss criteria:

BMI of 30kg/m2 or above, or
BMI of 27-30kg/m2 with additional factors.

This means people in the BMI categories of ‘obese’ and ‘overweight’. You can calculate your BMI here: NHS BMI Calculator.

How Effective is Mounjaro for Weight Loss?
Clinical trials have demonstrated that patients using Mounjaro®, in combination with a healthy diet and exercise, can lose up to 20% of their body weight and have often seen greater weight loss compared to other available therapies.
Patients often experience both decreased appetite and better metabolic health, including improvements in blood sugar control, which can be a great benefit for patients in midlife.

How does it work?
Mounjaro® (tirzepatide) is an injectable medication taken once a week. It mimics two naturally occurring hormones in the body:

GLP-1 (glucagon-like peptide-1), which controls appetite, suppressing hunger and slowing digestion.
GIP (glucose-dependent insulinotropic polypeptide), which works in conjunction with GLP-1 to help control blood sugar and increase feelings of fullness.

How Mounjaro Helps With Fat Loss?

A common question among women considering weight loss treatment is, does Mounjaro burn fat? Mounjaro does not directly burn fat. Instead, it helps regulate appetite, reduces hunger and increases feelings of fullness, making it easier to maintain a calorie deficit. Over time, this can help the body use stored fat for energy and support weight loss.

During perimenopause and menopause, hormonal changes can affect how fat is distributed around the body, particularly around the abdomen. Mounjaro may help eligible women manage their weight as part of a personalised treatment plan that includes healthy eating, physical activity and ongoing clinical support.

Reduce Appetite

Weight loss injections work by targeting hormones that control appetite and satiety, leading to a reduction in hunger and a significant decrease in appetite. With reduced hunger, it becomes easier to create and maintain a calorie deficit, which is necessary for effective weight loss.

Feel Fuller

The injections help people feel fuller for longer periods, reducing the urge to snack between meals or overeat. This can help with weight loss by reducing calorie intake and making it easier to maintain a calorie deficit.

Improve Cardio Health

Weight loss injections can support cardio health by helping reduce excess body weight. This can help reduce the risk of heart disease, high blood pressure, and other related conditions, leading to improved overall heart health.

How do I use Mounjaro?
Mounjaro is administered bysubcutaneous injection (under the skin) once weekly. At MenoClinic will instruct you in proper injection technique, safe handling, and rotation of injection sites to ensure that treatment remains as comfortable and effective as possible.

What dosage of Mounjaro will I need?
Treatment usually starts with a lower introductory dose 2.5mg so your body can get used to it. The dose is then gradually increased based on your tolerance and clinical response. Your MenoClinic clinician will design a personalised dosing schedule for you and monitor your response closely.

What are the potential side effects of Mounjaro?

Women considering Mounjaro for weight management often want to understand how treatment might affect them, particularly during perimenopause and menopause. When researching Mounjaro side effects in females, it is important to know that common effects include nausea, diarrhoea, constipation and vomiting. These are often more noticeable when starting treatment or increasing the dose and may improve as the body adjusts.

Although the common side effects are broadly similar in men and women, individual experiences vary. Women experiencing menopausal symptoms may benefit from discussing their medical history, current medication and weight management goals with a qualified healthcare professional before starting treatment.

As with all prescription medications, Mounjaro may cause side effects.

The most common side effects seen are only temporary and ease as your body adjusts to the medication:

Loss ofappetite
Nausea and/or vomiting
Diarrhoea or constipation
Heartburn or reflux
Headaches or dizziness
Abdominal pain
Fatigue
Burping and flatulence
Fast pulse
Mild allergic reaction, itching or bruising at the injection site

Less common, but more serious side effects may include pancreatitis, gallbladder problems, or increase in calcitonin ( a hormone that helps control calcium levels). We will review these with you as part of your consultation prior to starting treatment.

How long can I use Mounjaro®?
Our clinical team will monitor your weight with each order so we can ensure this product is effective for you. After 6 months of taking your highest tolerated dose, we will evaluate your progress. In order for us to keep prescribing Mounjaro® to you, you’ll need to have lost approximately 5% of your starting body weight. You may be able to continue using it for up to 2 years with clinical support.

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Frequently asked questions

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The weight loss results seen in clinical studies have achieved significant and sustained weight loss over a period. Some patients lost over 15–20% of their initial body weight with mounjaro in combination with healthy eating and activity. Individual results will vary due to lifestyle and individual response.

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Mounjaro is typically only prescribed to adults who have:

A Body Max Index (BMI) of 30 or above, or
A Body Max Index (BMI) of 27 or above with weight-related health conditions, such as high blood pressure, high cholesterol, or type 2 diabetes

You’ll need to book a consultation with a qualified prescriber who will confirm if you meet the eligibility criteria.

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Patients must be over 18 with a BMI and have four or more of the following diagnosed conditions to qualify for Mounjaro on the NHS:

Type 2 diabetes
High blood pressure (hypertension)
Heart disease (cardiovascular disease)
Obstructive sleep apnoea

Abnormal blood fats (dyslipidaemia)

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It is given as an injection under the skin (subcutaneous injection) once per week (into the abdomen, thigh, or upper arm). Most people self-inject after being shown the correct technique by their clinician.

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Treatment is usually initiated at a low introductory dosebefore being titrated upwards. The exact dose and schedule will depend on factors such as your medical history, response, and tolerability. A tailored plan will be provided by your clinician.

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Yes, Mounjaro must be kept in the fridge, where the temperature is between 2°C and 8°C before first use. Once you start using the pen, you can store it for 6 weeks either at room temperature (below 30°C) or in the fridge. Do not freeze Mounjaro.

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The most common side effects of Mounjaro are nausea, vomiting, diarrhoea, constipation, and loss of appetite. These effects are generally mild and improve over time. Rare but more serious risks will be discussed during your consultation.

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Mounjaro is injected once a week. It is important to inject on the same day each week, so pick a day that suits your schedule and set up a reminder on your phone or calendar. This will help your body to adjust and will also be easier to remember.

Friday or Saturday are often good choices, as this means that any side effects you experience (e.g. nausea, fatigue) will have time to subside, and you can adjust your schedule without the pressures of the workday. For anyone prone to binge eating or overeating over the weekend, injecting near the end of the week (e.g.Thursday or Friday) can also help to reduce cravings, allowing for more mindful consumption over the weekend.

On the other hand, other people prefer early-week injections (e.g. Monday) in order to reinforce good habits and create structure throughout the week.

Monjaro Patient Information Leaflet (PIL) information.

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When selecting an injection site, ensure you select a location where you can see the pen window and it is easily accessible.

Select an injection site: on your upper arms, stomach or the front of your thighs. It does not matter which injection site you select, you can choose whichever one is most comfortable for you.
Rotate your injection site every week. This will help to minimise skin reactions.

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Needles after use must be placed in your sharps bin (or suitable sharps container) and then cover with the pen cap after injecting the dose for that day. Store in the refrigerator until the next dose is required. Finished pens can be placed in general waste.

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In individuals with personal or family history of thyroid cancer, or if you have Multiple Endocrine Neoplasia Syndrome type 2 (MEN 2). MenoClinic clinicians will take a full medical history to assess any contraindications before commencing treatment.
If you are pregnant or planning a pregnancy, Mounjaro is not advisable.

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Yes. Mounjaro may reduce the absorption of contraceptives, particularly when your doses are being adjusted. In such cases, an additional method of contraception may be advised. Your prescriber will discuss safe options with you.

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Yes, the British Menopause Society (BMS) has recommended anyone taking oral progesterone or tablet form HRT to increase progesterone protective cover and/or use a barrier contraceptive method when starting treatment and increasing doses for 4 weeks.

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Yes, usually, but be cautious. There’s some evidence to suggest that Mounjaro may also lower your blood pressure, mostly due to its effects from weight loss.

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If the dose of Mounjaro you are currently taking is out of stock, you have the following options:

Change to a lower dosage – This may affect your appetite. Speak to our clinician before doing this.
Skip a dose – Speak to our clinician before doing this.

Switch to an alternative weight loss treatment. You may look to switch over to Wegovy. This is possible, however,you would need to speak to our clinician before you do this. Be advised that you will be started on the most appropriate dose of Wegovy, lowest dose (0.25mg). Please reach out to us before you run out of your dose so we can determine the most suitable treatment option for you.

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The structured wrap-around care support is about good nutrition to support health and increasing physical activity. It’s designed for people on tirzepatide, to help you get the most from your treatment, and maximise your ability to achieve and sustain healthy weight loss.

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Yes, you can switch your weight loss treatment from Mounjaro to Wegovy. Please note that:

You should consult with our clinican before making any changes
You will start any new treatment from the most appropriate dose?

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If you wish to switch your weight loss treatment, you will need to:

Complete a new consultation with us
Complete your current dose of Mounjaro. You cannot take Mounjaro and Wegovy at the same time as this increases the risk of possible side effects.
Wait at least one week after your last Mounjaro injection

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No, we cannot accept a return of weight loss medication if you change your mind.

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